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1

Structure–activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists

John W. Huffman, Gulay Zengin, Ming-Jung Wu, Jianzhong Lu, George Hynd, Kristen Bushell, Alicia L.S. Thompson, Simon Bushell, Cindy Tartal, Dow P. Hurst, Patricia H. Reggio, Dana E. Selley, Michael P.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 546 KB

english, 2005

2

Treatment implications of comorbid psychopathology in American Indians and Alaska Natives

R. Dale Walker, M. Dow Lambert, Patricia Silk Walker, Daniel R. Kivlahan

Journal:

Culture, Medicine, and Psychiatry

Year:

1992-1993

Language:

english

File:

PDF, 1.01 MB

english, 1992-1993

3

3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor

John W Huffman, Ross Mabon, Ming-Jung Wu, Jianzhong Lu, Richard Hart, Dow P Hurst, Patricia H Reggio, Jenny L Wiley, Billy R Martin

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 333 KB

english, 2003

4

Conformational Memories and the Endocannabinoid Binding Site at the Cannabinoid CB1 Receptor

Barnett-Norris, Judy, Hurst, Dow P., Lynch, Diane L., Guarnieri, Frank, Makriyannis, Alex, Reggio, Patricia H.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 506 KB

english, 2002

5

After 8 Months have Passed: Long-term Recall of Events by 1- to 2-year-old Children

Bauer, Patricia J., Hertsgaard, Louise A., Dow, Gina Annunziato

Journal:

Year:

1994

Language:

english

File:

PDF, 1.71 MB

english, 1994

6

FDA Approval Summary: Trabectedin for Unresectable or Metastatic Liposarcoma or Leiomyosarcoma Following an Anthracycline-Containing Regimen

Barone, Amy, Chi, Dow-Chung, Theoret, Marc R., Chen, Huanyu, He, Kun, Kufrin, Dubravka, Helms, Whitney S., Subramaniam, Sriram, Zhao, Hong, Patel, Anuja, Goldberg, Kirsten B., Keegan, Patricia, Pazdur

Journal:

Clinical Cancer Research

Year:

2017

Language:

english

File:

PDF, 556 KB

english, 2017

7

The Nucleotide-Free State of the Cannabinoid CB2/Gi Complex

Lynch, Diane L., Hurst, Dow P., Reggio, Patricia H.

Journal:

Year:

2020

Language:

english

File:

PDF, 453 KB

english, 2020

8

Essential and reactive alcoholism: A review

R. Dale Walker, Patricia Silk Walker, Frances Maloy, Matthew Owen Howard, M. Dow Lambert, Richard T. Suchinsky

Journal:

Journal of Clinical Psychology

Year:

1996

Language:

english

File:

PDF, 1.35 MB

english, 1996

9

Conformational memories with variable bond angles

Robert M. Whitnell, Dow P. Hurst, Patricia H. Reggio, Frank Guarnieri

Journal:

Journal of Computational Chemistry

Year:

2008

Language:

english

File:

PDF, 1.24 MB

english, 2008

10

Isocratic high-performance liquid chromatographic method for the separation of testosterone metabolites

Patricia Sanwald, Evelyn A. Blankson, Bertrand D. Duléry, Josiane Schoun, Norman D. Huebert, James Dow

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1995

Language:

english

File:

PDF, 586 KB

english, 1995

11

Use of electrospray ionization liquid chromatography-mass spectrometry to study the role of CYP2D^ in the in vitro metabolism of 5-hydroxytryptamine receptor antagonists

Patricia Sanwald, Murielle David, James Dow

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1996

Language:

english

File:

PDF, 521 KB

english, 1996

12

Ligand-Binding Architecture of Human CB2 Cannabinoid Receptor: Evidence for Receptor Subtype-Specific Binding Motif and Modeling GPCR Activation

Ying Pei, Richard W. Mercier, Jenine K. Anday, Ganesh A. Thakur, Alexander M. Zvonok, Dow Hurst, Patricia H. Reggio, David R. Janero, Alexandros Makriyannis

Journal:

Chemistry & Biology

Year:

2008

Language:

english

File:

PDF, 614 KB

english, 2008

13

Analogs of JHU75528, a PET ligand for imaging of cerebral cannabinoid receptors (CB1): Development of ligands with optimized lipophilicity and binding affinity

Hong Fan, Evangelia Kotsikorou, Alexander F. Hoffman, Hayden T. Ravert, Daniel Holt, Dow P. Hurst, Carl R. Lupica, Patricia H. Reggio, Robert F. Dannals, Andrew G. Horti

Journal:

European Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 887 KB

english, 2009

14

Unexplained hepatitis C virus antibody seroconversion in established blood donors

Patricia E. Hewitt, John A.J. Barbara, Kate Soldan, Jean PierreAUain, Brian C. Dow

Journal:

Transfusion (Wiley)

Year:

1997

Language:

english

File:

PDF, 218 KB

english, 1997

15

Reproducibility of hepatitis C virus antibody detection with various confirmatory assays

Jean-Pierre Main, Patricia E. Hewitt, John A.J. Barbara, Brian C. DOW, Eddie A.C. Follett, Fiona Davidson

Journal:

Transfusion (Wiley)

Year:

1997

Language:

english

File:

PDF, 199 KB

english, 1997

16

Agonist alkyl tail interaction with cannabinoid CB1 receptor V6.43/I6.46 groove induces a helix 6 active conformation

Judy Barnett-Norris, Dow P. Hurst, Kurt Buehner, Juan A. Ballesteros, Frank Guarnieri, Patricia H. Reggio

Journal:

International Journal of Quantum Chemistry

Year:

2002

Language:

english

File:

PDF, 680 KB

english, 2002

17

Synthesis and pharmacology of 1-methoxy analogs of CP-47,497

John W. Huffman, Seon A. Hepburn, Patricia H. Reggio, Dow P. Hurst, Jenny L. Wiley, Billy R. Martin

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 592 KB

english, 2010

18

Candidates for Treasurer

JAMES W DOW, PATRICIA J LYON

Journal:

Anthropology News

Year:

1989

Language:

english

File:

PDF, 305 KB

english, 1989

19

A critical role for a tyrosine residue in the cannabinoid receptors for ligand recognition

Sean D. McAllister, Qing Tao, Judy Barnett-Norris, Kurt Buehner, Dow P. Hurst, Frank Guarnieri, Patricia H. Reggio, Katharine W. Nowell Harmon, Guy A. Cabral, Mary E. Abood

Journal:

Biochemical Pharmacology

Year:

2002

Language:

english

File:

PDF, 621 KB

english, 2002

20

Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling

Hui Zheng, Elizabeth A Pearsall, Dow P Hurst, Yuhan Zhang, Ji Chu, Yali Zhou, Patricia H Reggio, Horace H Loh, Ping-Yee Law

Journal:

BMC Cell Biology

Year:

2012

Language:

english

File:

PDF, 3.03 MB

english, 2012

21

Adamantyl Cannabinoids: A Novel Class of Cannabinergic Ligands

Lu, Dai, Meng, Zhaoxing, Thakur, Ganesh A., Fan, Pusheng, Steed, John, Tartal, Cindy L., Hurst, Dow P., Reggio, Patricia H., Deschamps, Jeffrey R., Parrish, Damon A.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 490 KB

english, 2005

22

The Bioactive Conformation of Aminoalkylindoles at the Cannabinoid CB1 and CB2 Receptors: Insights Gained from (E)- and (Z)-Naphthylidene Indenes

Reggio, Patricia H., Basu-Dutt, Sharmista, Barnett-Norris, Judy, Castro, Marie T., Hurst, Dow P., Seltzman, Herbert H., Roche, Michael J., Gilliam, Anne F., Thomas, Brian F., Stevenson, L. A.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 209 KB

english, 1998

23

Practice guidelines in the addictions: Recent Developments

R. Dale Walker, Matthew Owen Howard, Patricia Silk Walker, M. Dow Lambert, Richard Suchinsky

Journal:

Journal of Substance Abuse Treatment

Year:

1995

Language:

english

File:

PDF, 1.20 MB

english, 1995

24

Effects of prototypicality on categorization in 1- to 2-year-olds: Getting down to basic

Patricia J. Bauer, Gina Annunziato Dow, Louise A. Hertsgaard

Journal:

Cognitive Development

Year:

1995

Language:

english

File:

PDF, 1.74 MB

english, 1995

25

Accepting and exempting the unexpected: 30-month-olds' generalization of event knowledge

Patricia J Bauer, Gina Annunziato Dow, Kathleen A Bittinger, Jennifer A Wenner

Journal:

Cognitive Development

Year:

1998

Language:

english

File:

PDF, 2.41 MB

english, 1998

26

Patients' use of health-teaching materials at three readability levels

Mary C. Dowe, Patricia A. Lawrence, John Carlson, Thomas C. Keyserling

Journal:

Applied Nursing Research

Year:

1997

Language:

english

File:

PDF, 680 KB

english, 1997

27

Endogenous lipid activated G protein-coupled receptors: Emerging structural features from crystallography and molecular dynamics simulations

Hurst, Dow P., Schmeisser, Marianne, Reggio, Patricia H.

Journal:

Chemistry and Physics of Lipids

Year:

2013

Language:

english

File:

PDF, 2.12 MB

english, 2013

28

The Importance of Hydrogen Bonding and Aromatic Stacking to the Affinity and Efficacy of Cannabinoid Receptor CB 2 Antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]- N -[(1 S ,2 S ,4 R )-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide (SR144528)

Kotsikorou, Evangelia, Navas, Frank, Roche, Michael J., Gilliam, Anne F., Thomas, Brian F., Seltzman, Herbert H., Kumar, Pritesh, Song, Zhao-Hui, Hurst, Dow P., Lynch, Diane L., Reggio, Patricia H.

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.39 MB

english, 2013

29

A Novel Pain Management Paradigm: Conformational Studies of the Mu-Opioid Receptor

Poole, Elizabeth, Iliff, Hadley, Edwards, Brady, Hurst, Dow, Reggio, Patricia

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 39 KB

english, 2009

30

Peptide Binding Site Determination Using Conformational Memories and MMC

Hurst, Dow P., Whitnell, Robert M., Lynch, Diane L., Reggio, Patricia H.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 35 KB

english, 2009

31

Identification of an Endogenous Allosteric Modulator's Binding Site at the Human Cannabinoid-1 Receptor, using the Forced-Biased Metropolis Monte Carlo Simulated Annealing Method (Mmc)

Shore, Derek M., Hurst, Dow P., Reggio, Patricia H.

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 39 KB

english, 2014

32

Molecular Dynamics Study of 2-Arachidonoyl-Sn-Glycero-3-Phosphoinositol (2-AGPI) and Lysophosphatidylinositol (LPI) in a POPC Bilayer and their GPR55 Docking Sites

Kotsikorou, Evangelia, Madrigal, Karla E., Lynch, Diane L., Hurst, Dow P., Abood, Mary E., Reggio, Patricia H.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 35 KB

english, 2010

33

Secondary-Structure Analysis of Human Peripheral Cannabinoid Receptor CB2 Based on Solid-State 13C-,15N-MAS NMR and Molecular Dynamics Simulations

Kimura, Tomohiro, Vukoti, Krishna, Lynch, Diane L., Hurst, Dow P., Grossfield, Alan, Pitman, Michael C., Reggio, Patricia H., Yeliseev, Alexei A., Gawrisch, Klaus

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 36 KB

english, 2010

34

A specific Role for Cholesterol at the Mu Opioid Homodimer Interface

Lynch, Diane L., Poole, Elizabeth B., Hurst, Dow P., Law, Ping Y., Pitman, Michael C., Reggio, Patricia H.

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 37 KB

english, 2011

35

Rational Design of Neutral Allosteric Modulators of the CB1 Receptor with Improved Receptor Interactions and Unique Pharmacology

Shore, Derek M., Hurst, Dow P., Navas, Frank J., Seltzman, Herbert H., Baillie, Gemma L., Ross, Ruth A., Reggio, Patricia H.

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 55 KB

english, 2013

36

Construction of a μ-Opioid Receptor Model using Conformational Memories

Poole, Elizabeth, Hurst, Dow, Reggio, Patricia, Law, Ping-Yee

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 43 KB

english, 2010

37

Backtalk: February Articles on Teachers Bring Kudos and Commentary

John Gindele, Neva R. Vogel, James Raths, Roger S. Dow, Mihaly Csikszentmihalyi, Nancy Sharts Engel, Loye Miller, Patricia E. Howlett, Maurice Miller, Gregory R. Anrig and Harold R. Huff

Journal:

The Phi Delta Kappan

Year:

1986

Language:

english

File:

PDF, 1.19 MB

english, 1986

38

An Aromatic Microdomain at the Cannabinoid CB 1 Receptor Constitutes an Agonist/Inverse Agonist Binding Region

McAllister, Sean D., Rizvi, Gulrukh, Anavi-Goffer, Sharon, Hurst, Dow P., Barnett-Norris, Judy, Lynch, Diane L., Reggio, Patricia H., Abood, Mary E.

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 621 KB

english, 2003

39

Exploration of Biologically Relevant Conformations of Anandamide, 2-Arachidonylglycerol, and Their Analogues Using Conformational Memories

Barnett-Norris, Judy, Guarnieri, Frank, Hurst, Dow P., Reggio, Patricia H.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 329 KB

english, 1998

40

Residues Accessible in the Binding-Site Crevice of Transmembrane Helix 6 of the CB2 Cannabinoid Receptor †

Nebane, Ntsang M., Hurst, Dow P., Carrasquer, Carl A., Qiao, Zhuanhong, Reggio, Patricia H., Song, Zhao-Hui

Journal:

Year:

2008

Language:

english

File:

PDF, 5.02 MB

english, 2008

41

What do older Australians want?

Dow, Briony, Sparrow, Patricia, Moore, Kirsten, Gaffy, Ellen, Yates, Ian

Journal:

Australasian Journal on Ageing

Year:

2013

Language:

english

File:

PDF, 113 KB

english, 2013

42

Global fold of human cannabinoid type 2 receptor probed by solid-state 13 C-, 15 N-MAS NMR and molecular dynamics simulations

Kimura, Tomohiro, Vukoti, Krishna, Lynch, Diane L., Hurst, Dow P., Grossfield, Alan, Pitman, Michael C., Reggio, Patricia H., Yeliseev, Alexei A., Gawrisch, Klaus

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2014

Language:

english

File:

PDF, 961 KB

english, 2014

43

Allosteric Modulation of a Cannabinoid G Protein-coupled Receptor

Shore, Derek M., Baillie, Gemma L., Hurst, Dow H., Navas, Frank, Seltzman, Herbert H., Marcu, Jahan P., Abood, Mary E., Ross, Ruth A., Reggio, Patricia H.

Journal:

Journal of Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 4.03 MB

english, 2014

44

Molecular-Interaction and Signaling Profiles of AM3677, a Novel Covalent Agonist Selective for the Cannabinoid 1 Receptor

Janero, David R., Yaddanapudi, Suma, Zvonok, Nikolai, Subramanian, Kumar V., Shukla, Vidyanand G., Stahl, Edward, Zhou, Lei, Hurst, Dow, Wager-Miller, James, Bohn, Laura M., Reggio, Patricia H., Macki

Journal:

ACS Chemical Neuroscience

Year:

2015

Language:

english

File:

PDF, 1.03 MB

english, 2015

45

Synthesis, pharmacological evaluation and docking studies of pyrrole structure-based CB2 receptor antagonists

Ragusa, Giulio, Gómez-Cañas, María, Morales, Paula, Hurst, Dow P., Deligia, Francesco, Pazos, Ruth, Pinna, Gerard A., Fernández-Ruiz, Javier, Goya, Pilar, Reggio, Patricia H., Jagerovic, Nadine, Garcí

Journal:

European Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.90 MB

english, 2015

46

One for the Price of Two…Are Bivalent Ligands Targeting Cannabinoid Receptor Dimers Capable of Simultaneously Binding to both Receptors?

Glass, Michelle, Govindpani, Karan, Furkert, Daniel P., Hurst, Dow P., Reggio, Patricia H., Flanagan, Jack U.

Journal:

Trends in Pharmacological Sciences

Year:

2016

Language:

english

File:

PDF, 2.75 MB

english, 2016

47

MAPPING CANNABINOID RECEPTOR 1 ALLOSTERIC SITE(S): CRITICAL MOLECULAR DETERMINANT AND SIGNALING PROFILE OF GAT100 - A NOVEL, POTENT AND IRREVERSIBLY BINDING PROBE

Laprairie, Robert B., Kulkarni, Abhijit R, Kulkarni, Pushkar M, Hurst, Dow P., Lynch, Diane L., Reggio, Patricia H., Janero, David R., Pertwee, Roger G., Stevenson, Lesley A., Kelly, Melanie, Denovan-

Journal:

ACS Chemical Neuroscience

Year:

2016

Language:

english

File:

PDF, 722 KB

english, 2016

48

Beta-Arrestin Biased Signaling at a Class a GPCR: Modeling the ORG27569 Induced CB1/Beta-Arrestin 1 Complex

Hurst, Dow P., Lynch, Diane L., Shore, Derek M., Pitman, Michael C., Reggio, Patricia H.

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 37 KB

english, 2015

49

Global Fold of Human Cannabinoid Type 2 Receptor Probed by Solid-State NMR and Molecular Dynamics Simulations

Kimura, Tomohiro, Vukoti, Krishna, Lynch, Diane L., Hurst, Dow P., Grossfield, Alan, Pitman, Michael C., Reggio, Patricia H., Yeliseev, Alexei A., Gawrisch, Klaus

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 40 KB

english, 2015

50

Identification of an Endogenous Allosteric Modulator's Binding Site at the Human Cannabinoid-1 Receptor, Using Forced-Biased Metropolis Monte Carlo Simulated Annealing Method (MMC) and Molecular Dynamics

Shore, Derek M., Hurst, Dow P., Lynch, Diane L., Reggio, Patricia H.

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 43 KB

english, 2015

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